| Autor: |
Shishito, Sentaro, Shibuya, Shozo, Sasaki, Keiichi, Shibuya, Masayoshi, Kato, Hiroaki, Imabayashi, Kenichi, Ozu, Keisuke, Ohnuma, Tetsutaro, Kaiho, Hiroo, Sugawara, Keiji, Nakano, Nobumichi, Kato, Masakazu, Yamanaka, Masao, Nitta, Kiichi, Matsushita, Shozaburo, Adachi, Kuniaki, Saito, Katsuyuki, Saito, Takeshi, Miyata, Koyo, Takeuchi, Mutsuo, Chiba, Ryuichi, Kurosawa, Masaya, Shio, Nobuo |
| Jazyk: |
japonština |
| Rok vydání: |
1976 |
| Předmět: |
|
| Zdroj: |
泌尿器科紀要. 22(2):157-176 |
| ISSN: |
0018-1994 |
| Popis: |
Fosfomycin (FOM, 2 g/day, p.o.) and Cephalexin (CEX, I g/day, p.o.) were administered to 132 cases of acute urinary tract infections, and the efficacy of these drugs was compared with double blind procedure. Except 2 drop-out cases, which bad not visited the hospital after the first administration of the drugs, I in FOM-group and I in CEX-group, the background of 130 cases were analyzed according to 33 articles, and it was to be satisfied in its uniformity as the subject of this trial. The final evaluation of therapeutic effect of each drug was decided according to the individual evaluation of the effect on urinary microorganism, urinary findings, and general status of the patient, except the side-effect. These results were analyzed statistically, and no significant difference was observed between these evaluations. Furthermore, X2-test, Wilcoxon's procedure, and calculation of several coefficients of correlation were carried out, but any significant difference between the action of these drugs could not be observed. As the side-effect, 6 of slight GI-tract symptoms, and increase in serum transaminase in 3 cases were observed in FOM-group, while, slight sickness in 2 cases, increase of serum transaminase in 4 cases, and increase of jaundice index in I case were observed in CEX-group, respectively. But all of these were slight and temporary, and these needed neither suspension of the drug administration nor some available therapies. With the results obtained above, it was concluded that FOM and CEX should have almost the same therapeutic effect on the simple acute urinary tract infections. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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