| Autor: |
Utsuki, Satoshi, Oka, Hidehiro, Fujii, Kiyotaka, Miyoshi, Norio, Ishizuka, Masahiro, Takahashi, Kiwamu, Inoue, Katsushi |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Zdroj: |
In hope of going over the present Clinical PD and PDT-A Symposium Book in "PACIFICHEM 2010". :160-173 |
| Popis: |
Protoporphyrin IX (PPIX) is known to accumulate within human brain tumors following administration of 5-aminolevulinic acid (5-ALA). It then emits red fluorescence when exposed to ultraviolet light. On this basis, 5-ALA is often utilized intraoperatively to assist with the surgical resection of malignant gliomas. However, there is little knowledge of metabolic intermediates generated during 5-ALA conversion to PPIX. We therefore conducted an investigation of both serum and urinary intermediates in patients with brain tumors (n=40) and in healthy volunteers (n=8). Study subjects were each given a 1.0 gm oral dose of 5- ALA, undergoing blood and urinary porphyrin determinations prior to and four hours after dosing. While baseline porphyrin levels did not differ significantly between groups, urinary levels of coproporphyrins (I and III), and serum levels of uroporphyrins (I and III) at four hours were significantly higher in patients with brain tumors than in control subjects. The higher porphyrin levels corresponded with the strongest intraoperative PPIX fluorescence. Observed porphyrin elevations were subsequently attributed to efflux of metabolites after 5-ALA uptake by tumor cells. A rise in urinary coproporphyrin following 5-ALA challenge may thus have a role as a nonspecific tumor marker. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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