| Autor: |
Ito, Hiroshi, Shidahara, Miho, Takano, Harumasa, Takahashi, Hidehiko, Nozaki, Syoko, Suhara, Tetsuya |
| Jazyk: |
angličtina |
| Rok vydání: |
2007 |
| Zdroj: |
Annals of Nuclear Medicine. 21(6):355-360 |
| ISSN: |
0914-7187 |
| Popis: |
Objective The lung is one of the key organs for determining the distribution of drugs in the human body. Various factors infl uence the accumulation of drugs. In this study, we investigated the effects of smoking on drug distribution to the lung using radiolabeled drugs. Methods We measured the lung uptake of [11C] (+)McN5652, a radioligand for serotonin transporter (5-HTT), and inactive enantiomer [11C](−)McN5652 in 19 healthy men (12 nonsmokers and 7 smokers) using positron emission tomography. Pretreatment study was performed by the administration of clomipramine (50 mg), a potent 5-HTT inhibitor. Results The mean lung uptake of [11C](+)McN5652 and [11C](−)McN5652 was signifi cantly higher in smokers than in nonsmokers. The lung uptake of [11C](+)McN5652 decreased after pretreatment with clomipramine, whereas that of [11C](−)McN5652 was not affected by clomipramine. Conclusions Lung uptake of [11C](−)McN5652 was in fl uenced by smoking, possibly because the probable nonspecifi c binding accumulation was changed as [11C] (−)McN5652 was reported to have negligible affi nity to 5-HTT. Smoking might be one of the important factors when distribution of radioligands is considered. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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