Usefulness of PET-guided surgery with 64Cu-labeled cetuximab for resection of intrapancreatic residual tumors in a xenograft mouse model of resectable pancreatic cancer

Autor: Igarashi, Chika, Yoshii, Yukie, Tashima, Hideaki, Iwao, Yuma, Sakurai, Kohei, Hihara, Fukiko, Tachibana, Tomoko, Yoshida, Eiji, Wakizaka, Hidekatsu, Akamatsu, Go, Yamaya, Taiga, Yoshimoto, Mitsuyoshi, Matsumoto, Hiroki, Ming-Rong, Zhang, Nagatsu, Kotaro, Sugyo, Aya, Tsuji, Atsushi, Higashi, Tatsuya, Chika, Igarashi, Yukie, Yoshii, Hideaki, Tashima, Yuma, Iwao, Kohei, Sakurai, Fukiko, Hihara, Tomoko, Tachibana, Eiji, Yoshida, Hidekatsu, Wakizaka, Go, Akamatsu, Taiga, Yamaya, Hiroki, Matsumoto, Zhang, Ming-Rong, Kotaro, Nagatsu, Aya, Sugyo, Atsushi, Tsuji, Tatsuya, Higashi
Jazyk: angličtina
Rok vydání: 2021
Zdroj: Nuclear medicine communications. 42(10):1112-1121
ISSN: 0143-3636
Popis: In pancreatic cancer surgery, accurate identification and resection of intrapancreatic residual tumors are quite difficult. We have developed a novel open-typed PET system (called 'OpenPET'), which enables high-resolution PET-guided surgery in real time, and demonstrated that OpenPET-guided surgery with intraperitoneally administered 64Cu-labeled anti-epidermal growth factor receptor antibody cetuximab is useful to detect and resect primary pancreatic cancer. Here, we investigated applicability of OpenPET-guided surgery for unexpected residual intrapancreatic tumors and examined its survival benefit over conventional surgery.
Databáze: OpenAIRE