Diffusion of sulbactam and cefoperazone into the prostatic tissue
| Autor: | OKAMURA, Kiyoharu, HASHIMOTO, Hiroshi, MORIKAWA, Mitsuru, NISHIHARA, Masayuki, SAGA, Yuji, YACHIKU, Sunao, OSANAI, Hiroaki, YAMAUCHI, Kaoru |
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| Jazyk: | japonština |
| Rok vydání: | 1989 |
| Předmět: | |
| Zdroj: | 泌尿器科紀要. 35(4):727-734 |
| ISSN: | 0018-1994 |
| Popis: | 前立腺摘除術を受けた20症例にSBT/CPZを2 g投与し, 1時間後に血清および前立腺組織内について同一の条件下で採取し, SBT, CPZ濃度を測定した.1)血清濃度はCPZの方がSBTより有意に(p Diffusion of sulperazone (SBT) and cefoperazone (CPZ) into the prostatic tissue was studied in 20 cases. Two g of SBT/CPZ was injected intravenously and 1 hour later, prostatic tissue was obtained surgically and venous blood was drawn simultaneously. The serum concentration of CPZ (58.0 micrograms/ml +9.2) was higher than that of SBT (25.9 micrograms/ml +/- 9.3) and the prostatic tissue concentration of CPZ (14.9 micrograms/ml +/- 6.1) was higher than that of SBT (10.9 micrograms +/- 6.1). However, the SBT concentration ratio of prostatic tissue to serum level (P/S ratio) was significantly higher (42.5%) than that of CPZ (25.9%). The SBT concentration in the prostatic tissue was high enough to enhance the antibacterial activity of CPZ. SBT/CPZ was appraised to be an effective chemotherapeutic agent for infections of prostate caused by susceptible organisms, especially by beta-lactamase producing bacteria. |
| Databáze: | OpenAIRE |
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