The early effect of Gamma knife surgery for brain metastases

Autor: Fukuoka, Seiji, Seo, Yoshinobu, Takanashi, Masami, Nakagawara, Jyoji, Takahashi, Shuhei, Sasaki, Takehiko, Nakamura, Jun-Ichi, Suematsu, Katsumi
Jazyk: angličtina
Rok vydání: 1994
Předmět:
Zdroj: 北海道脳神経疾患研究所医誌 = Journal of Hokkaido Brain Research Foundation. 7(1):12-18
ISSN: 1340-5764
Popis: One hundred and sixty lesions in 68 patients with brain metastases were treated with gamma knife. Thirty four patients had multiple metastases. The mean follow-up was 8.3 months ( 1 to 25 months). More than 50 % reduction rate of tumors were observed 88% of all lesions in one month, 90% in final follow-up. Mean Karnofsky performance status score raised in values from 75% to 89% in one month after gamma knife surgery. Progressive neurological symptoms improved in 89 % of patients with symptoms within one week. Recurrences occurred in 4 %, and transient neurological deteriorations were observed in 7 % of all patients. No permanent deficits was recognized. The median survival was 10 months of all patients ,while 9 months in single lesion and 13 months in multiple lesions respectively. There was no significant difference between these two groups (p=0.96). These data may indicate that gamma knife surgery has rapid effect for brain metastases and is effective for even multiple brain metastases.
Databáze: OpenAIRE