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Cognitive challenge is a late effect of childhood cancer survival. This study examined the effectiveness of CogEvo （Total Brain Care ［TBC］, Kobe, Japan）, a computerized evaluation system, in assessing neuropsychological dysfunctions that are difficult to identify among children who have experienced therapeutic exposure, radiation therapy, chemotherapy, surgical therapy, and hematopoietic cell transplantation. In all, 30 childhood survivors who attended a long-term follow-up clinic at the Children’s Cancer Center between April 2017 and December 2019 were assessed using CogEvo software, and 23 were assessed using the Wechsler Intelligence Scale for Children, Fourth Edition （WISC-IV）. Basic profile information （diagnosis and treatment） was also obtained. In all, 18 participants received central nervous system-directed therapies （CNS group）, and 12 did not （non-CNS group）. We found that in these childhood survivors, the spatial cognition and memory scores registered by CogEvo were significantly correlated with the scores on the WISC-IV perceptual reasoning index （PRI） in terms of spatial cognition （r＝0.52） and memory （r＝0.48）. Furthermore, orientation （p＜0.01） and spatial cognition （p＝0.01） scores were lower in the CNS group than in age-matched control subjects in the TBC database. The CogEvo results were related to certain elements of the PRI in WISC-IV and may measure visuospatial cognition. Cognitive weakness assessed on the PRI in the CNS group can be detected using CogEvo. CogEvo may complement WISC-IV to measure sensitive outcomes of cognitive function in childhood survivors who have experienced therapeutic exposure. |
