| Popis: |
In the present report, it was clarified whether or not cancer markers, namely prostate specific antigen (PSA) and gamma-seminoprotein (γ-Sm ), could predict the prognosis for recurrent prostate cancer. Of 139 patients who were diagnosed with prostate cancer over a ten year period between January 1989 and December 1998, data obtained from 43 patients with recurrent prostate cancer were statistically analyzed. Levels of PSA andγ-Sm were measured using the enzyme immunoassay (EIA) method. These patients with relapse prostate cancer were divided into two groups with respect to the median of each marker. Differences in survival periods following relapse were compared by the Kaplan-Meier method. Although PSA andγ-Sm/PSA ratio did not have any statistically significant effect on survival, the 50% survival for the lowγ-Sm group (2 years and 7 months) was significantly longer than that for the highγ-Sm group (1 year and 2 months). Also, theγ-Sm/PSA ratio at the time of relapse was significantly lower than that at the initial treatment. As a result, even though PSA was totally ineffective in predicting prognosis following relapse,γ-Sm was shown to be a useful prognostic factor following relapse. |
