Extramedullary T lymphoid blast crisis representing an additional translocation t(6;8)(q25;q22) in a patient with Ph-positive CML after allogeneic bone marrow transplantation

Autor:	Okazuka, Kiyoshi, Toba, Ken, Kawai, Kazuhiro, Nikkuni, Koji, Tsuchiyama, Junjiro, Momoi, Akihito, Kanazawa, Naoko, Nagai, Koich, Suzuki, Noriatsu, Aizawa, Yoshifusa
Jazyk:	angličtina
Rok vydání:	2001
Předmět:	chronic myelogenous leukemia hemic and lymphatic diseases bone marrow transplantation extramedullary crisis T-lymphoblastic crisis chromosome translocation
Zdroj:	Leukemia Research. 25(12):1089-1094
ISSN:	0145-2126
Popis:	A patient with extramedullary crisis from CML after allogeneic BMT is reported. A pathological neck lymph node observed after transplantation revealed pre-T lymphoblastic phenotype, and the FISH analysis showed recipient type sex chromosomes and bcr/abl fusion gene. The cells represented an additional translocation, t(6;8) (q25;q22). No rearrangements of the TCR β, γ or δ chain genes were observed. The absence of TCR rearrangement indicated the clonogenic involvement of pluripotent hematopoietic stem cells by Ph chromosome. Bone marrow specimens at that time showed donor type sex chromosomes and no bcr/abl-positive cells by FISH.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=jairo_______::691f1750aeff9377260e2e802b959f0c https://niigata-u.repo.nii.ac.jp/records/2158 Zobrazit plný text záznamu Full Text from ScienceDirect