| Popis: |
Vesicoureteral reflux, pyelonephritis, a low compliance bladder, and urethral overactivity are thought to be risk factors for renal deterioration in patients with spina bifida. We studied the relationship between these factors and renal function as shown by intravenous pyelography or ^Tc-dimercaptosuccinic acid (DMSA) renal uptake in spina bifida patients. All four factors were found to be related to upper tract deterioration, and especially reflux was closely related to renal function. In addition, we studied the changes of filling cystometry parameters after antireflux surgery in spina bifida patients with secondary reflux. After antireflux surgery, the bladder capacity, maximum resting pressure, and bladder compliance all changed, and in patients who had grade 4 or 5 reflux, the changes were quite marked. |
