Noninvasive embryo evaluation method combining timelapse images with biomarkers in follicular fluid and serum

Autor: Rumi, Nakazawa, Takehiko, Matsuyama, Atsuko, Shiota
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: 日本IVF学会雑誌. 24(1):10-18
ISSN: 1881-9028
Popis: To increase the success rate of assisted reproductive technologies, embryos with high developmental and implantation potential should be identified and selected. Here, we sought to establish a noninvasive and highly accurate embryo selection method by combining time-lapse monitoring parameters( at S2 and S3) with the following biomarkers in the follicular fluid( FF) and serum samples obtained from study subjects( using 70 eggs, FF, and serum in 58 cycles of conventional in vitro fertilization [c-IVF]): dehydroepiandrosterone sulfate( DHEA-S), insulin-like growth factor 1 (IGF- 1), reactive oxygen metabolites (d-ROMs), biological antioxidant potential (BAP), and an oxidative stress index (OSI: d-ROMs/BAP × 100). Our analyses revealed significant positive correlations between some of the biomarkers in FF and serum: DHEA-S( r=0.88; p
Databáze: OpenAIRE