EXPRESS: Further observations on the behavioral and neural effects of bone marrow stromal cells in rodent pain models

Autor: Guo, Wei, Chu, Yu Xia, Imai, Satoshi, Yang, Jia Le, Zou, Shiping, Mohammad, Zaid, Wei, Feng, Dubner, Ronald, Ren, Ke
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Molecular Pain. 12:1-12
ISSN: 1744-8069
Popis: Background: Bone marrow stromal cells (BMSCs) have shown potential to treat chronic pain, although much still needs to be learned about their efficacy and mechanisms of action under different pain conditions. Here, we provide further convergent evidence on the effects of BMSCs in rodent pain models. Results: In an orofacial pain model involving injury of a tendon of the masseter muscle, BMSCs attenuated behavioral pain conditions assessed by von Frey filaments and a conditioned place avoidance test in female Sprague-Dawley rats. The antihyperalgesia of BMSCs in females lasted for
Databáze: OpenAIRE