Clinical role of C-11-methionine-PET/CT in detection of adrenal metastasis from lung cancer
| Autor: | Ohashi, Seiya, Yoshikawa, Kyosan, Toubaru, Sachiko, Hasebe, Mitsuhiko, Ishikawa, Hiroyuki, Sagou, Kenji, Tamura, Katsumi, Tanimoto, Katsuyuki, Kandatsu, Susumu, Mizoe, Junetsu, Fukumura, Toshimitsu, Saga, Tsuneo, Kawaguchi, Koji, Kamada, Tadashi |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Popis: | Phase I/II clinical trial on carbon ion radiotherapy (CIRT) has been conducted in patients with non-small cell lung cancer (NSCLC) in our institute, and we use C-11-methionine (MET) PET/CT for staging and monitoring treatment of NSCLC. Adrenal gland is one of common sites of metastasis from NSCLC. The objective of this study was to determine if MET-PET/CT could distinguish adrenal metastasis from benign gland. Materials and Methods: We performed a retrospective review of patients with NSCLC and found 125 cases evaluated with MET-PET/CT, Toshiba Aquiduo, who treated by CIRT and followed more than 2 years from 2006 to 2009. There were 71 adenocarcinoma, 48 squamous cell carcinoma and 6 other carcinoma. Five patients in these 125 patients proved developing adrenal metastasis, three in left adrenal gland and 2 in right adrenal gland. All these 5 adrenal lesions were histologically proved. We evaluated statistically, non-pared t-test, the difference between normal left and right adrenal gland MET uptake, and then we compared MET uptake in adrenal metastasis with normal adrenal gland. We analyzed the ability of MET-PET/CT for differential diagnosis by receiver operating characteristic (ROC) analysis. Results: Mean MET uptake of left and right normal adrenal gland was 3.9-2.0 and 2.8-1.0, respectively. There was significant difference in MET uptake of normal adrenal gland between left and right (p EANM'11 - Annual Congress of the European Association of Nuclear Medicine |
| Databáze: | OpenAIRE |
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