| Autor: |
Shono, Yusuke, Toubai, Tomomi, Ota, Shuichi, Ibata, Makoto, Mashiko, Shinobu, Hirate, Daisuke, Miura, Yoko, Umehara, Shintaro, Toyoshima, Nobuyasu, Tanaka, Junji, Asaka, Masahiro, Imamura, Masahiro |
| Jazyk: |
angličtina |
| Rok vydání: |
2006 |
| Předmět: |
|
| Zdroj: |
Clinical and Laboratory Haematology. 28(5):351-354 |
| ISSN: |
0141-9854 |
| Popis: |
A 33-year-old woman underwent unrelated cord blood transplantation (U-CBT) for myelodysplastic syndrome (MDS)-related secondary AML. She showed impressive increases in the number of CD19+ B cells in bone marrow and CD19+27-IgD+ B cells in peripheral blood from about 1 month to 3 months after U-CBT. The serum level of IL-6 temporarily increased after transplantation, and this increase seemed to be correlated with the expansion of CD19+ B cells. Although compared with BMT, little is known about the kinetics of hematological and immunological reconstitution in U-CBT, there was initial B-cell recovery after CBT as some described. This B cell recovery may be associated with a high number of B-cell precursors present in cord blood (CB). The phenomenon of naive B lymphocyte expansion that we found might be associated with a high number of B-cell precursors present in CB. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
