Role of the Capillary Invasion Index: A Prognostic Indicator for Adenocarcinoma of the Esophagogastric Junction
| Autor: | Kawahira, Hiroshi, Yoshida, Yutaka, Urita, Tasuku, Takagi, Ryuichi, Oshiro, Takashi, Okazumi, Shinichi |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Toho Journal of Medicine. 5(1):13-19 |
| ISSN: | 2189-1990 |
| Popis: | Original Article Introduction: Adenocarcinoma which occurs in the esophagogastric junction (EGJ) does not have a clear answer with regards to surgical procedures and the prognosis. In the present study, prognostic evaluation factors, including patient characteristics and results of pathological examination were evaluated. Methods: The present study included 29 patients with adenocarcinoma of the EGJ who underwent R0 surgery at our department between January 2007 and December 2016. Univariate and multivariate analysis were conducted to examine the associations of age, sex, tumor size, histopathological type, depth of tumor invasion, lymph node metastasis, pathological disease stage, neoadjuvant and adjuvant chemotherapy, and lymphatic and vascular invasion index or “LV Index" as prognostic factors for survival. The log-rank test was used to determine differences in survival between groups for each factor. Results: On pathological examination, the median maximum tumor size was 33 mm (range: 11-113 mm), and the median location of the center of the tumor relative to the EGJ was 13 mm distal to the EGJ (range: 7 mm proximal to the EGJ to 20 mm distal to the EGJ). For the LV Index, the hazard ratio was 0.136 (95% confidence interval (CI)), (0.016-1.171; P = 0.069) on univariate analysis, and 0.102 (95% CI, 0.009-1.115; P = 0.061) on multivariate analysis. Survival rate was significantly different between the high and low LV Index groups (P = 0.033, log-rank test). Conclusions: Evaluation of prognosis in patients who underwent R0 resection for adenocarcinoma of EGJ at our hospital showed that the LV Index based on the lymphatic and vascular invasion contributes to survival as a prognostic factor. |
| Databáze: | OpenAIRE |
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