| Autor: |
Tanabe, Yoko, Hashimoto, Michio, Haque, Abdul Md., Sugioka, Kozo, Katakura, Masanori, Hara, Toshiko, Shido, Osamu |
| Jazyk: |
angličtina |
| Rok vydání: |
2005 |
| Zdroj: |
Shimane journal of medical science. 22(2):29-34 |
| ISSN: |
0386-5959 |
| Popis: |
Twenty-two 5-week-old male Wistar rats fed an n-3 fatty acid-adequate diet were supplemented with docosahexaenoic acid (DHA) administered perorally for 14 weeks. Six weeks after the start of the administralion, the rats were for 5 weeks trained to acquire a reward at the end of each of 4 arms of an 8-arm radial maze. The retention test interposed with a delayed task (20-min interval after acquiring the first 2 rewards) was then given to each rat to determine spatial working memory retention DHA administration reduced the number of working memory errors after the 20-min interval in the retention test and tended to induce an increase in the DHA/arachidonic acid ratio in the hippocampus, indicating that chronic administration of DHA to rats fed an n-3 fatty acid-adequate diet is conducive to the improvement of working memory-related learning abiiity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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