Foresight into a new transdermal absorption study of cosmetics: how to evaluate transdermal absorption and skin concentration of cosmetics?
| Jazyk: | japonština |
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| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | フレグランスジャーナル |
| ISSN: | 0288-9803 |
| Popis: | Skin permeation experiments have been broadly done since 1970s to 80s as an evaluation method for transdermal drug delivery systems．In cosmetic formulations，skin concentration of active ingredients is more important than their skin permeation，because primary target site of the active ingredients is skin surface or skin tissues．Nevertheless，little investigation was carried out on the test method of skin concentration after application of cosmetic formulations. Recently we investigated an estimating method of skin concentration of the chemical compounds from their skin permeation profiles. In the study，we took care of "3Rs" issues for animal experiments、We have proposed an equation which was capable to estimate animal or human skin concentration from permeation pofile through the artificial membrane （silicone membrane) and animal skin． The silicone membrane was found to be useful as an alternative membrane to human or animal skin for predicting human skin concentration of chemical compounds，bocause an extremely excellent extrapolation to animal or human skin concentration was attained by calculation using the silicone membrane permeation data. We review present our paper and relative studies． 特集 化粧品科学の新たな視点を探る |
| Databáze: | OpenAIRE |
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