| Autor: |
Ishiwata, Kiichi, Ogi, Nobuo, Hayakawa, Nobutaka, Oda, Keiichi, Nagaoka, Tsukasa, Toyama, Hinako, Suzuki, Fumio, Endo, Kazutoyo, Tanaka, Akira, Senda, Michio |
| Jazyk: |
angličtina |
| Rok vydání: |
2002 |
| Zdroj: |
Annals of Nuclear Medicine. 16(7):467-475 |
| ISSN: |
0914-7187 |
| Popis: |
We proposed ［11C］KF18446 as a selective radioligand for mapping the adenosine A2A receptors being highly enriched in the striatum by positron emission tomography(PET). In the present study ,we investigated whether ［11C］KF18446 PET can detect the change in the striatal adenosine A2A receptors in the rat after unilateral injection of an excitotoxin quinolinic acid into the striatum,a Huntington's disease model, to demonstrate the usefulness of ［11C］KF18446.The extent of the striatal lesion was identified based on MRI, to which the PET was co-registered.The binding potential of ［11C］KF18446 significantly decreased in the quinolinic acid-lesioned striatum. The decrease was comparable to the decrease in the potential of ［11C］raclopride binding to dopamine D2 receptors in the lesioned striatum,but seemed to be larger than the decrease in the potential of ［11C］SCH23390 binding to dopamine D1 receptors. Ex vivo and in vitro autoradiography validated the PET signals.We concluded that ［11C］KF18446 PET can detect change in the adenosine A2A receptors in the rat model, and will provide a new diagnostic tool for characterizing post-synaptic striatopallidal neurons in the stratum. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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