Artesunate, a potential drug for treatment of Babesia infection

Autor: Goo, Youn-Kyoung, Terkawi, M. Alaa, Jia, Honglin, Aboge, G. Oluga, Ooka, Hideo, Kim, Suk, Igarashi, Ikuo, Nishikawa, Yoshifumi, Xuan, Xuenan
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Zdroj: Parasitology International. 59(3):481-486
ISSN: 1383-5769
Popis: application/pdf
The effect of artesunate, a water-soluble artemisinin derivative, against Babesia species, such as Babesia bovis, Babesia gibsoni, and Babesia microti was studied. Cultures of B. bovis and B. gibsoni were treated with 0.26 μM, 2.6 μM, 26 μM, and 260 μM artesunate, and the growth-inhibitory effect was shown in over 2.6 μM artesunate in day 4 and day 3 post-subculture for B. bovis and B. gibsoni, respectively, in dose-dependent manner. In vivo experiment for B. microti, strong inhibition effects were observed in mouse groups treated with over 1.0 mg/kg body weight of artesunate on day 9 and 10 post-infection. These results suggest that artesunate could be a potential drug for Babesia infection.
Databáze: OpenAIRE
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