Genotype Determination of Hepatitis C Virus Strains in Malaysia
| Autor: | Zheng, Wei-Yun, Hasebe, Futoshi, Ali, Ayub, Sinniah, Mangalam, Saraswathy, T. S., Ooi, Beng Geok, Igarashi, Akira |
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| Jazyk: | angličtina |
| Rok vydání: | 1996 |
| Předmět: | |
| Zdroj: | 熱帯医学 Tropical medicine. 38(2):51-60 |
| ISSN: | 0385-5643 |
| Popis: | Out of 12 patient sera obtained from Malaysia, seven sera (7/12) were found to contain hepatitis C virus (HCV) genome by nested RT-PCR with universal HCV specific primers which were derived from 5' noncoding region (5' NCR). Genotype determination of these 7 Malaysian HCV strains were carried out both by subtype-specific core amplification system (Okamoto et al., 1992 and 1993) and sequencing in the 5' NCR. Four Malaysian strains were major genotype 1 (two of subtype II/1b, one of subtype I/1a and one of co-infection with I/1a + II/1b). The genotypes of 3 remaining strains were determined as major genotype 3 by nucleotide sequences in the 5' NCR. The results showed that HCV major genotype 1, 2 and 3 are common in the world, especially in Asian countries including Malaysia. 熱帯医学 Tropical medicine 38(2). p51-60, 1996 |
| Databáze: | OpenAIRE |
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