Graft rejection and hyperacute graft-versus-host disease in stem cell transplantation from non-inherited maternal antigen complementary HLA-mismatched siblings
| Autor: | Okumura, Hirokazu, Yamaguchi, Masaki, Kotani, Takeharu, Sugimori, Naomi, Sugimori, Chiharu, Ozaki, Jun, Kondo, Yukio, Yamazaki, Hirohito, Chuhjo, Tatsuya, Takami, Akiyoshi, Ueda, Mikio, Ohtake, Shigeki, Nakao, Shinji |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: | |
| Zdroj: | European Journal of Haematology. 78(2):157-160 |
| ISSN: | 0902-4441 |
| Popis: | 金沢大学大学院医学系研究科機能再生学 Human leukocyte antigen (HLA)-mismatched stem cell transplantation from non-inherited maternal antigen (NIMA)-complementary donors is known to produce stable engraftment without inducing severe graft-versus-host disease (GVHD). We treated two patients with acute myeloid leukemia (AML) and one patient with severe aplastic anemia (SAA) with HLA-mismatched stem cell transplantation (SCT) from NIMA-complementary donors (NIMA-mismatched SCT). The presence of donor and recipient-derived blood cells in the peripheral blood of recipient (donor microchimerism) and donor was documented respectively by amplifying NIMA-derived DNA in two of the three patients. Graft rejection occurred in the SAA patient who was conditioned with a fludarabine-based regimen. Grade III and grade IV acute GVHD developed in patients with AML on day 8 and day 11 respectively, and became a direct cause of death in one patient. The findings suggest that intensive conditioning and immunosuppression after stem cell transplantation are needed in NIMA-mismatched SCT even if donor and recipient microchimerisms is detectable in the donor and recipient before SCT. © 2007 The Authors. |
| Databáze: | OpenAIRE |
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