| Autor: |
Rumiana, Bakalova, Zhelov, Zhivko, Nikolova, Billiana, Murayama, Shuhei, Lazarova, Desislava, Tsoneva, Idana, Aoki, Ichio, Saga, Tsuneo |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Zdroj: |
General Physiology and Biophysics. 34(4):393-398 |
| ISSN: |
0231-5882 |
| Popis: |
The present study was designed to investigate whether poly-ion complex hollow vesicles (polymersomes), based on chemically-modified chitosan, are appropriate for lymph node mapping in the context of their application in the development of theranostic nanosized drug delivery systems (nano-DDS). The experiments were performed on Balb/c nude mice (colon cancer-grafted). The mice were subjected to anesthesia and quantum dot (QD705)-labeled polymersomes (d~120 nm) were injected intravenously via the tail vein. The optical imaging was carried out on Maestro EX Imaging System (excitation filter: 435–480 nm; emission filter: 700 nm). A strong fluorescent signal, correspondingto QD705 fluorescence, was detected in thelymph nodes, as well as in the tumor. A very weak fluorescent signal was found in the liver area. The half-life of QD705-labelled polymersomeswas 6 ± 2 hours in the bloodstream and 11 ± 3 hours in the lymph nodes. The data suggest that polymersomes are very promising carriers for lymph node mapping using QD as a contrast agent. They are useful matrix for development of nano-formulations with theranostic capabilities. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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