血管新生加齢黄斑変性に対する抗血管内皮増殖因子治療での4年間の追跡調査における急性視力低下の発生率と原因の検討
| Jazyk: | angličtina |
|---|---|
| Rok vydání: | 2023 |
| Předmět: |
Intravitreal ranibizumab (IVR)
Treat-and-extend (TAE) regimen Intravitreal aflibercept (IVA) Real-world date Treatment-naïve neovascular AMD Age-related macular degeneration (AMD) Macular neovascularization (MNV) Long-term follow-up Acute vision loss Anti-vascular endothelial growth factor (VEGF) treatment |
| Zdroj: | Retina. |
| ISSN: | 0275-004X |
| Popis: | Purpose: To investigate the incidence, risk factors, and outcomes of patients with age-related macular degeneration (AMD) who experienced acute vision loss despite periodic injections of anti-vascular endothelial growth factor (VEGF) treatment for 4 years.Methods: This retrospective cohort study included patients who were diagnosed with treatment-naïve neovascular AMD and completed a 4-year follow-up. The incidence and risk factors for the occurrence of three or more lines of visual loss at every check-up were investigated.Results: The analysis included 76 eyes of 76 patients. Acute vision loss occurred in 30 eyes (39.5%) over 4 years. Lower baseline best collected visual acuity (BCVA) and disrupted ellipsoid zone were independent predictors of vision loss occurrence. Although the causes and timing of visual acuity loss varied, retinal pigment epithelium tears were observed only in the first year. Most (86.7%) patients who experienced vision loss recovered their vision to pre-loss levels at least once; however, the final BCVA was worse than that in the group that did not experience acute vision loss.Conclusion: Approximately half of the patients with AMD experienced acute vision loss during a 4-year, despite continuous anti-VEGF treatment. Most patients recovered from vision losses temporarily; however, they experienced worse visual outcomes subsequently. 長崎大学学位論文 学位記番号:博(医歯薬)甲第1506号 学位授与年月日:令和5年3月20日 Author: Machida, Akira; Oishi, Akio; Tsuiki, Eiko; Maekawa, Yuki; Kurihara, Junko; Hirata, Yuki; Machida, Eriko; Kitaoka, Takashi Citation: Retina, article in press. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|