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Tolerance to lethal ischemia can be induced in gerbils by prior subjection to non-lethal ischemia. The sequential changes og ubiquitin immunoreactivity in the hippocampi of gerbils subjected to non-lethal ischemia followed by lethal ischemia were investigated. The double-ischemic group was subjected to non-lethal ischemia followed by lehtal ischeima, the single-ischemic group was subjected to lethal ischemia, only, the sham-ischemic qroup was subjected to sham operation followed by lethal ischemia. The densities of the CA (Cornu ammonis) 1 neurons were assessed by hematoxylin-eosin staining. In the double-ischemic group, the extent of the neuronal damage was less than that in the single-ischemic and sham ischemic groups (both P |
