Safety and influence of molecular hydrogen/carbon dioxide contained drinking water on common anthropometric and laboratory parameters
| Jazyk: | japonština |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | 山口医学. 70(3):109-118 |
| Popis: | 近年,分子状水素には強い抗酸化作用のあることが多数報告され,蘇生後脳症や急性心筋梗塞の虚血後再灌流では過酸化物質が発生して組織障害を起こす.分子状水素はこの新しい治療法として注目されている.一方,健常人への水素ガス投与効果については,まだ詳しく検証されていない.本研究では健常者ボランティアを対象に1000mL/日の炭酸ガス含有飲用水(CO_2摂取期間),または水素/炭酸ガス含有飲用水(H_2/CO_2摂取期間)を各々31日間の飲用のうち26日間以上摂取できた者で比較し,P Background:Recently, it has been shown that hydrogen gas has a strong antioxidant effect. Therefore, molecular hydrogen is drawing attention as a new therapeutic strategy against tissue damage caused by peroxides in post-ischemic reperfusion injury. Methods:In the present study, we investigated the effect of consuming 1000 ml/day of either carbonated water(CO_2-water)or hydrogen-molecule-added carbonated water(H_2/CO_2-water)for 26 days on physiological and laboratory parameters. Thirty-nine healthy volunteers were recruited and put on either of the water regimens using a cross-over design with 31-day washout period. Results:Among physiological parameters, SPO_2 significantly increased by 0.43% after drinking CO_2-water, whereas after drinking H_2/CO_2-water, systolic and diastolic blood pressure decreased significantly by 5.2 and 2.8 mmHg, respectively, and H_2 concentrations in end-expiratory air increased by 38% although statistically not significant. As for the biochemical and blood cell parameters, by the CO_2-water regimen, total bilirubin, γ-GTP, cholinesterase, CK-MB, Ca, erythrocyte and platelet counts significantly decreased(P |
| Databáze: | OpenAIRE |
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