Radiation-Induced Teratogenetic Effect and Adaptive Response in Late Organogenesis in Mice
| Autor: | Bing, Wang, Ohyama, Harumi, Tanaka, Kaoru, Morimoto, Yasuko, Aizawa, Shirou, Yukawa, Osami, Hayata, Isamu |
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| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: | |
| Popis: | The limb developing system is a suitable model to study the teratogenetic effect of radiation in fetal mice. We found that radiation-induced apoptosis in the predigital regions of fetal limb buds was responsible for digital defects. In ICR and C57BL/6J mice, and C57BL/6J mice with different Trp53 gene status susceptibility to the radiation-induced apoptosis and digital defects was depending on the strain as well as Trp53 gene status and radiation dose. C57BL/6J mice were more radiosensitive than ICR mice. Trp53 wild-type C57BL/6J mice appeared to be the most radiosensitive and Trp53 knockout C57BL/6J mice the most radioresistant. An adaptive response (reduction of both fetal death and malformation) was demonstrated in fetal mice induced by priming low dose radiation prior to a high dose irradiation. Suppression of the digital defects was correlated to the inhibition of apoptosis. The priming dose was mouse strain-related. Both Trp53 alleles were essential for induction of the adaptive response. Furthermore, existence of the dose-rate effect was verified in both radiation-induced teratogenetic effect and adaptive response. The results indicate that Trp53-dependent apoptosis mediates radiation-induced digital defects and the Trp53 involves in the adaptive response in late organogenesis. Radiation-induced teratogenetic effect and adaptive response are due to a complex interplay between dose, dose rate and animal factors such as the strain, developmental stage, and gene background. The Fifth Japan-France Workshop on Radiobiology and Medical Imaging |
| Databáze: | OpenAIRE |
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