血液がん患者の好中球減少に伴う発熱の危険因子としての口腔細菌および口腔免疫との関連

Autor: Sogawa, Yuka, Fukui, Makoto, Nakamura, Shingen, Sogabe, Kimiko, Sumitani, Ryohei, Yoshioka, Masami, Abe, Masahiro, Hinode, Daisuke
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: International Journal of Hematology. 112(6):851-859
ISSN: 0925-5710
Popis: The aim of this study is to investigate the association between chemotherapy-induced fever with neutropenia less than 1,500/μL (FwN) and oral bacteria and/or oral immunity in patients with hematological cancer. Thirty-two patients with hematological cancer were enrolled in the study. Secretory immunoglobulin A (sIgA) in saliva and the anaerobic bacteria in tongue coating of each subject was assessed before the first chemotherapy. Eleven subjects had an onset of FwN and 21 subjects did not during the observation periods. It was revealed by the cox-proportional hazard model analysis that the levels of sIgA were low (HR 0.98, p
Databáze: OpenAIRE