Arising of Oral Squamous Cell Carcinoma in a Patient with Long-standing Lichen Planus：a Case Report
| Autor: | Mika, Ishikawa, Tadaaki, Sasaki, Hiroshi, Kato, Hirotate, Iwase |
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| Jazyk: | japonština |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Dokkyo Journal of Medical Sciences. 48(2):103-111 |
| ISSN: | 0385-5023 |
| Popis: | 口腔扁平苔癬は口腔粘膜の角化異常を伴う慢性炎症性疾患である．中高年の女性に多く，好発部位は頬粘膜，臨床型は網状型が多いと報告されている．疫学調査では有病率は 0.5～2.6％と言われており，臨床において遭遇頻度が比較的高い疾患である．しかし，稀に扁平上皮癌への悪性転化が生じると報告されている．口腔扁平苔癬の悪性化については 1971 年の WHO 分類（第 1 版）時でも報告されており，2017 年の WHO 分類（第 4版）では従来の口腔前癌病変と口腔前癌状態の概念が統合され，Oral potentially malignant disorders と定義された．今回われわれは，口腔扁平苔癬の診断を受け約 23 年後に悪性化した扁平上皮癌の 1 例を経験したので，若干の文献的考察を加えて報告する． Oral lichen planus is a chronic inflammatory disease associated with abnormal keratinization of the oral mucosa. Although the details regarding the etiology are unknown, it has been reported that its onset frequently occurs in middle-aged and elderly women, the site of predilection is the buccal mucosa, and the reticular type is the most com-mon clinical form. On the basis of epidemiological studies, the prevalence of this condition is indicated to be 0.5％-2.6％ . Thus, it is a disease that is encountered relatively frequently in clinical practice. However, it has been report-ed that the malignant progression to squamous cell carci-noma rarely occurs. The malignancy of oral lichen planus was reported in 1971 in the World Health Organization（WHO）Histological Typing of Oral and Oropharyngeal Tumors（1st edition）, and the definition of oral lichen pla-nus was revised in the 2017 WHO classification. In the 2017 WHO Classification of Head and Neck Tumors（4th edition）, it was proposed to combine the conventional con-cepts of precancerous lesions of the mouth and precancer-ous conditions of the mouth into oral potentially malignant disorders. Here, we report our experience with a case of squamous cell carcinoma that became malignant about 23 years after diagnosis of oral lichen planus, which was newly classified as an oral potentially malignant disorder, along with a review of the literature. |
| Databáze: | OpenAIRE |
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