Measurement of Liver Stiffness for Primary Biliary Cholangitis using Shear Wave Elastography
| Autor: | Kenji, Uchiyama, Ryosaku, Shirahashi, Toshikuni, Suda, Masaki, Inagaki, Sayuki, Kobayashi, Kosuke, Haruki, Masaya, Tamano |
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| Jazyk: | japonština |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Dokkyo Journal of Medical Sciences. 47(3):137-143 |
| ISSN: | 0385-5023 |
| Popis: | 目的：原発性胆汁性胆管炎（Primary Biliary Cholangitis，以下PBC）患者の肝硬度を測定し，肝硬度の臨床的意義について検討した．方法：Shear wave elastography（SWE）によって剪断波の伝播速度（Vs）が測定された43例のPBC を対象とした．無症候性PBC（aPBC），症候性PBC（sPBC）と正常対象（Control）とのVsを比較した．次にVsと臨床パラメーター，FIB-4 indexとの相関について検討した．結果：Control群のVs平均は1.20±0.11 m/s， aPBC群とsPBC群は同様に1.43±0.21 m/s， 1.66±0.23 m/sであり，ControlとaPBC，およびaPBCとsPBCの間に有意差を認めた．Vs はALTとFIB-4 indexと正の相関を，アルブミン，血小板，プロトロンビン活性と負の相関を認めた．ALT値30 U/L 未満の活動性肝炎を有さないPBCでは，Vsに寄与する独立因子としてFIB-4 indexが抽出された．結論：SWEによるVsの測定はPBCの進行度を予測できる． Purpose：We examined the clinical significance of liver stiffness in patients with primary biliary cholangitis（PBC）.Methods：We included a total of 43 patients with PBC whose shear wave propagation velocity （Vs） was measured using shear wave elastography（SWE）. Vs was compared among asymptomatic PBC patients（aPBC）, symptomatic PBC patients（sPBC）, and healthy controls（control）. The correlations between Vs and clinical parameters were examined.Result：Vs was significantly higher in the aPBC group compared with the control, and in the sPBC group compared with the aPBC group. Vs positively correlated with alanine aminotransferase and fibrosis-4 index, and negatively correlated with albumin, platelets, and prothrombin activity. In PBC patients without active hepatitis of less than ALT level 30, FIB-4 index was extracted as the independent factor which contributed to Vs.Conclusion：Measurement of Vs using SWE can predict the degree of PBC progression. |
| Databáze: | OpenAIRE |
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