Imaging of Hypoxic Tumor: Correlation between Diffusion-weighted MR Imaging and F-fluoroazomycin Arabinoside Positron Emission Tomography in Head and Neck Carcinoma

Autor: Imaizumi, Akiko, Obata, Takayuki, Kershaw, Jeff, Tachibana, Yasuhiko, Inubushi, Masayuki, Koizumi, Mitsuru, Yoshikawa, Kyosan, Ming-Rong, Zhang, Tanimoto, Katsuyuki, Harada, Rintaro, Uno, Takashi, Saga, Tsuneo, Kershaw, Jeffrey
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine. 19(3):276-281
ISSN: 1347-3182
Popis: We investigated the usefulness of diffusion-weighted imaging (DWI) for detecting changes in the structure of hypoxic cells by evaluating the correlation between F-fluoroazomycin arabinoside (FAZA) positron emission tomography activity and DWI parameters in head and neck carcinoma. The diffusion coefficient corresponding to the slow compartment of a two-compartment model had a significant positive correlation with FAZA activity (ρ = 0.58, P = 0.016), whereas the diffusional kurtosis from diffusion kurtosis imaging had a significant negative correlation (ρ = -0.62, P = 0.008), which suggests that those DWI parameters might be useful as indicators for changes in cell structure.
Databáze: OpenAIRE