大腸癌における抗EGFR抗体薬治療後のEGFR Downregulationは抗腫瘍効果を予測する

Autor: Okada, Yasuyuki, Kimura, Tetsuo, Nakagawa, Tadahiko, Okamoto, Koichi, Fukuya, Akira, Goji, Takahiro, Fujimoto, Shota, Sogabe, Masahiro, Miyamoto, Hiroshi, Muguruma, Naoki, Tsuji, Yasushi, Okahisa, Toshiya, Takayama, Tetsuji
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Molecular Cancer Research. 15(10):1445-1454
ISSN: 1541-7786
Popis: ABC, antibody-binding capacity; ADCC, antibody-dependent cellular cytotoxicity; ATCC, American Type Culture Collection; BSA, bovine serum albumin; CR, complete response; CRC, colorectal cancer; CT, computed tomography; ECACC, European Collection of Authenticated Cell Cultures; EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; ETS, early tumor shrinkage; FBS, fetal bovine serum; FISH, fluorescent in situ hybridization; HRP, horseradish peroxidase; HSRRB, Health Science Research Resources Bank; IHC, immunohistochemistry; MesNa, Mercaptoethanesulfonic acid sodium; mCRC, metastatic colorectal cancer; mAb, monoclonal antibody; mAbs, monoclonal antibodies; PARP, poly (ADP-ribose) polymerase; PBS, phosphate buffered saline; PD, progressive disease; p-ERK, phosphorylated ERK; PNA-LNA, peptide nucleic acid-locked nucleic acid; PR, partial response; PVDF, polyvinylidene difluoride; RECIST, Response Evaluation Criteria in Solid Tumors; RIKEN BRC, RIKEN BioResource Center; SD, stable disease; SDS, sodium dodecyl sulfate; SDS-PAGE, SDS-polyamide gel electrophoresis; TBS-T, Tris-buffered saline with 0.1% Tween; TGF-α, transforming growth factor-α.
Databáze: OpenAIRE