Study of clinical usefulness of an antiandrogen, TZP-4238, as a drug for treatment of benign prostatic hypertrophy--its influence on sexual function
| Autor: | Kumamoto, Yoshiaki, Tsukamoto, Taiji, Sato, Yoshikazu, Aoki, Masaharu, Umehara, Tsugio, Kubo, Takashi, Aoki, Hikaru, Matsuzaka, Junichi, Koiso, Kenkichi, Akaza, Hideyuki, Takeshima, Hitoshi, Kondo, Fukuji, Shimazaki, Jun, Akimoto, Susumu, Aso, Yoshio, Honma, Yukio, Sasaki, Yukihiro, Okada, Kiyoki, Nogaki, Joji, Yoshida, Hideki, Saito, Toyohiko, Watanabe, Masanobu, Shirai, Masafumi, Ishii, Nobuhisa, Osada, Takao, Yajima, Michitaka, Baba, Katsuyuki, Minagawa, Nobuhiko, Yoshida, Osamu, Arai, Yoichi, Komatsu, Yosuke, Matsuda, Tadashi, Mikami, Osamu, Ohara, Takashi, Isurugi, Koichiro, Hasegawa, Fumiaki, Araki, Tohru, Fujimoto, Hiroshi, Yuasa, Makoto, Kawanishi, Yasuo, Kumazawa, Joichi, Yamashita, Hiroshi, Takahashi, Koichi, Hara, Sanshin, Yamaguchi, Akito, Takei, Mineo, Nakashima, Mitsuyoshi |
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| Jazyk: | japonština |
| Rok vydání: | 1994 |
| Předmět: | |
| Zdroj: | 泌尿器科紀要. 40(8):745-759 |
| ISSN: | 0018-1994 |
| Popis: | 前立腺肥大症患者を対象としてTZP-4238 (TZP群)の性的機能に対する影響および自覚的排尿障害に対する有効性, 安全性, 有用性を酢酸クロルマジノン(CMA群)を対照薬にして, 二重盲検法により検討した。その結果, 性機能に与える影響はTZP 1.25mg/日投与群は45.1%, CMA 50mg/日投与群は71.4%と有意にTZP群が少ないこと, しかも排尿障害への臨床効果はTZP群45.9%, CMA群50.0%とほぼ同等であるという成績をえている。また他の副作用についても両薬剤間に差は認められなかった Using chlormadinone acetate (CMA) as the control drug, a double-blind study was carried out to examine not only the effects of 17 alpha-acetoxy-6-chloro-2-oxa-4, 6-pregnadiene-3, 20-dione (TZP-4238;) on subjective urinary symptoms but also, especially, that on the sexual function in patients with benign prostatic hypertrophy (BPH). The clinical efficacy rate in relation to the subjective urinary symptoms was about the same in the two treatment groups; 45.9% in the TZP-4238 group and 50.0% in the CMA group. However, the incidence of adverse effects on the sexual function showed a marked difference between the two groups. The TZP-4238 group revealed a lower suppressive effect on the function than the CMA group (45.1% vs. 71.4%). In relation to their causation of other adverse effects, there were no differences between the two drugs. Accordingly, in consideration of the facts that TZP-4238 with less influence on the sexual function affords a superior quality of life to elderly patients, while achieving effective treatment by means of a convenient single daily administration, TZP-4238 was surmised to be a more useful drug than CMA as an antiandrogen for the treatment of BPH. |
| Databáze: | OpenAIRE |
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