Effects of low dose lithium on hippocampal neuropathology in people at ultra-high risk for psychosis
| Autor: | Wood, Stephen J., Berger, Gregor, Dell'Ollio, Margaret, Hamer, Clare A., Wellard, R. Mark, Pell, Gaby S., Phillips, L. J., Nelson, Barnaby, Manji, Husseini, Jackson, Graeme J., Pantelis, Christos, McGorry, Patrick D. |
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| Rok vydání: | 2007 |
| Předmět: |
060104 Cell Metabolism
110000 MEDICAL AND HEALTH SCIENCES MRS hippocamus 110903 Central Nervous System 170112 Sensory Processes Perception and Performance 111601 Cell Physiology 170000 PSYCHOLOGY AND COGNITIVE SCIENCES psychosis 111603 Systems Physiology 060100 BIOCHEMISTRY AND CELL BIOLOGY 110904 Neurology and Neuromuscular Diseases 110902 Cellular Nervous System 110900 NEUROSCIENCES 100499 Medical Biotechnology not elsewhere classified MR spectroscopy 170100 PSYCHOLOGY 110199 Medical Biochemistry and Metabolomics not elsewhere classified 111600 MEDICAL PHYSIOLOGY 110100 MEDICAL BIOCHEMISTRY AND METABOLOMICS 060000 BIOLOGICAL SCIENCES litium 170200 COGNITIVE SCIENCE 170101 Biological Psychology (Neuropsychology Psychopharmacology Physiological Psychology) 170205 Neurocognitive Patterns and Neural Networks 060105 Cell Neurochemistry 060602 Animal Physiology - Cell neuropathy |
| Zdroj: | Biological Psychiatry |
| ISSN: | 2381-3652 |
| Popis: | Background: Indicated intervention prior to the onset of psychosis may help to delay, attenuate or even prevent the illness. To date, successful intervention trials using atypical antipsychotics and/or cognitive behavioural therapy have been reported, but it is not clear that these treatments are targeting the underlying brain pathology. Given our previous findings of progressive grey matter loss over the transition to psychosis, agents that can prevent this, such as lithium, might be useful for preventing or delaying the onset of psychosis. Methods: In this open-label trial, 11 ultra-high-risk patients who received low- dose lithium treatment for four months were compared with 10 similar patients who received only needs-based intervention. Magnetic resonance imaging, including T2 relaxometry and proton spectroscopy was performed prior to initiation of treatment and after four months. Results: Hippocampal T2 declined significantly in the treatment group (p=0.018). No significant group x time effects were seen for brain metabolites, although N-acetyl aspartate (NAA), myo-inositol, creatine and choline all tended to increase with lithium administration and decrease or remain unchanged in the comparison group. Conclusions: Decreased T2 relaxation time and increased concentrations of NAA are indicators of increased neuronal function/viability. Low-dose lithium may help regulate synaptic pruning and reduce neuronal dysfunction associated with the onset of psychosis. |
| Databáze: | OpenAIRE |
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