| Autor: |
SAYYAD, N, CELE, Z, ALETI, RR, BERA, M, CHERUKUPALLI, S, CHANDRASEKARAN, B, KUSHWAHA, ND, KARPOORMATH, R |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
IndraStra Global. |
| ISSN: |
2381-3652 |
| DOI: |
10.1002/2014GL060198 |
| Popis: |
We herein report a simple and highly efficient microwave-assisted, copper-catalyzed and ligand-free synthetic method for 2-substituted 4(3H)-quinazolinones as domino reaction. This reaction proceeds via self-condensation of substrate (2-bromo/iodo benzamide) in the presence of a strong base and copper catalyst. The substituted quinazolinones were obtained in one-pot reaction by intramolecular cyclization (condensation) via Ullmann-type intermediate. Both the intermediates and quinazolinones were obtained in good yield and can be further used as building blocks for developing the potential novel drug-like compounds. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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