Asymmetric synthesis of gamma-aminophosphonates: The bio-isosteric analogs of gamma-aminobutyric acid
| Autor: | BERA, K, NADKARNI, D, NAMBOOTHIRI, INN |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Isosteric Analogs
Enantioselective Synthesis Gamma-Aminophosphonic Acid Metabotropic Glutamate Receptors 2-Amino-4-Phosphonobutanoic Acids Gamma-Aminobutyric Acid Preliminary Biological Evaluation Diastereoselective Synthesis Chiral Sulfinyl Auxiliary Group-Iii Alpha-Amino Amino Phosphonic-Acids Conformationally Constrained Analogs |
| Zdroj: | IndraStra Global. |
| ISSN: | 2381-3652 |
| Popis: | The properties of aminophosphonates as transition state analogs of amino acids, and as antibacterial, antifungal and antiHIV agents attracted considerable attention in recent years. Although many reviews appeared in the literature covering alpha- and beta-aminophosphonates, gamma-aminophosphonates did not receive sufficient attention despite the fact that parent gamma-aminophosphonic acid and its derivatives are bio-isosteric analogs of GABA (gamma-amino butyric acid). This review provides a critical summary of the significance of gamma-aminophosphonates and various approaches to their synthesis, with particular emphasis to asymmetric versions. |
| Databáze: | OpenAIRE |
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