Late-Stage beta-Epimerization. A Stereodivergent to Stereoconvergent Relay to the First Total Synthesis of (+)-Murolic Acid

Autor:	FERNANDES, RA, PATIL, PH, CHOWDHURY, AK
Jazyk:	angličtina
Rok vydání:	2014
Předmět:	Driving Force Chelation Claisen Rearrangement Central-Asia Rearrangement Gamma-Butyrolactones Lichen Asymmetric Dihydroxylation Paraconic Acids Carboxylation Epimerization Total Synthesis Natural Products Glycolipids Asymmetric Synthesis
Zdroj:	IndraStra Global.
ISSN:	2381-3652
Popis:	The first total synthesis of (+)-murolic acid is accomplished in 17 steps from ester 9 in 14.8% overall yield. The key steps involve asymmetric dihydroxylation, orthoester Johnson-Claisen rearrangement and -methylenation using Stiles reagent. A beneficial late stage -epimerization reverted a stereodivergent relay to a stereoconvergent completion of an efficient synthesis of (+)-murolic acid.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=issn23813652::7f9f974b98221d82a4a4c4cddba53f36 http://dspace.library.iitb.ac.in/jspui/handle/100/16338 Zobrazit plný text záznamu