| Autor: |
Paz, Márcia Fernanda Correia Jardim, de Alencar, Marcus Vinícius Oliveira Barros, de Lima, Rodrigo Maciel Paulino, Sobral, André Luiz Pinho, do Nascimento, Glauto Tuquarre Melo, dos Reis, Cristiane Amaral, Coêlho, Maria do Perpetuo Socorro de Sousa, do Nascimento, Maria Luísa Lima Barreto, Gomes Júnior, Antonio Luiz, Machado, Kátia da Conceição, de Menezes, Ag-Anne Pereira Melo, de Lima, Rosália Maria Torres, de Oliveira Filho, José Williams Gomes, Dias, Ana Carolina Soares, dos Reis, Antonielly Campinho, da Mata, Ana Maria Oliveira Ferreira, Machado, Sônia Alves, Sousa, Carlos Dimas de Carvalho, da Silva, Felipe Cavalcanti Carneiro, Islam, Muhammad Torequl, de Castro e Sousa, João Marcelo, Melo Cavalcante, Ana Amélia de Carvalho |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Oxidative Medicine and Cellular Longevity. |
| ISSN: |
1942-0900 |
| DOI: |
10.1155/2020/3457890 |
| Popis: |
Omeprazole (OME) is commonly used to treat gastrointestinal disorders. However, long-term use of OME can increase the risk of gastric cancer. We aimed to characterize the pharmacological effects of OME and to correlate its adverse effects and toxicogenetic risks to the genomic instability mechanisms and cancer-based on database reports. Thus, a search (till Aug 2019) was made in the PubMed, Scopus, and ScienceDirect with relevant keywords. Based on the study objective, we included 80 clinical reports, forty-six in vitro, and 76 in vivo studies. While controversial, the findings suggest that long-term use of OME (5 to 40 mg/kg) can induce genomic instability. On the other hand, OME-mediated protective effects are well reported and related to proton pump blockade and anti-inflammatory activity through an increase in gastric flow, anti-inflammatory markers (COX-2 and interleukins) and antiapoptotic markers (caspases and BCL-2), glycoprotein expression, and neutrophil infiltration reduction. The reported adverse and toxic effects, especially in clinical studies, were atrophic gastritis, cobalamin deficiencies, homeostasis disorders, polyp development, hepatotoxicity, cytotoxicity, and genotoxicity. This study highlights that OME may induce genomic instability and increase the risk of certain types of cancer. Therefore, adequate precautions should be taken, especially in its long-term therapeutic strategies and self-medication practices. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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