| Autor: |
Stidham, Timothy, Reiter, Pamela D., Ford, Douglas M., Lum, Gary M., Albietz, Joseph |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
Case Reports in Pediatrics. |
| ISSN: |
2090-6803 |
| DOI: |
10.1155/2011/678724 |
| Popis: |
Vancomycin is routinely used for empiric antibiotic therapy in children. Higher-serum-concentration targets for serious infections are now being recommended. This recommendation may result in aggressive dosing with increased potential for toxicity. We report a case of a pediatric patient who developed vancomycin toxicity and associated oliguric renal failure who was treated effectively with high-flux hemodialysis for vancomycin toxicity, clearing serum concentrations of vancomycin by over 75% in only 6 hours (213.2 mcg/mL to 51.8 mcg/mL) with subsequent return to baseline renal function and without adverse sequelae. While not historically considered a viable option for drug removal in cases of toxicity, new high-flux hemodialysis techniques can remove significant percentages of vancomycin in short periods of time. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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