Association of Immune Thrombocytopenia and T-Lymphoblastic Lymphoma in a Pediatric Patient

Autor:	Denu, Ryan A., Matson, Daniel R., Davis, Matthew J., Tedford, Natalie J., Brichta, Christine E., Diamond, Carol A., Hoover-Regan, Margo L.
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Article Subject immune system diseases hemic and lymphatic diseases
Zdroj:	Case Reports in Hematology.
ISSN:	2090-6560
DOI:	10.1155/2019/1425151
Popis:	Immune thrombocytopenia (ITP) is characterized by isolated thrombocytopenia of unclear etiology. We present a unique case of an 8-year-old girl with chronic ITP who was subsequently diagnosed with T-lymphoblastic lymphoma at age 11. The clinical course was complicated by the occurrence of nonepileptiform events with bizarre behavior changes following the administration of nelarabine and intrathecal and high-dose systemic methotrexate. This case highlights an unusual co-occurrence of hematologic malignancy and chronic ITP in an otherwise healthy child. We speculate that underlying genetic or immunologic lesions may predispose a subset of pediatric ITP patients to the development of hematologic malignancies.
Databáze:	OpenAIRE
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