Avelumab-Induced Scleroderma in a Patient with Metastatic Squamous Cell Carcinoma of the Lung

Autor:	Dobrzynski, Jeffrey L., Vest, Blake E., Swick, Brian L.
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Article Subject
Zdroj:	Case Reports in Dermatological Medicine.
ISSN:	2090-6463
DOI:	10.1155/2022/5360113
Popis:	Immune checkpoint inhibitors are associated with a spectrum of cutaneous immune-related adverse events. While maculopapular eruptions are the most common cutaneous adverse event, scleroderma can rarely develop. Herein, we report a case of new-onset scleroderma associated with avelumab treatment in the setting of metastatic squamous cell carcinoma of the lung. The pathophysiology of immune checkpoint inhibitor-induced scleroderma is not completely understood. A proposed mechanism is discussed along with the clinical presentation of symptoms and associated therapeutic response in cancer treatment. This case contributes to the few existing reports of immune checkpoint inhibitor-induced scleroderma to better understand the implications in the management of cutaneous immune-related adverse events.
Databáze:	OpenAIRE
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