A Network Pharmacology Approach to Explore the Potential Mechanisms of Yifei Sanjie Formula in Treating Pulmonary Fibrosis

Autor: Qiao, Bo, Wu, Yueying, Li, Xiaoya, Xu, Zhenyuan, Duan, Weigang, Hu, Yanan, Jia, Wenqing, Fan, Qiuyang, Xing, Haijing
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Evidence-Based Complementary and Alternative Medicine.
ISSN: 1741-427X
DOI: 10.1155/2020/8887017
Popis: Objective. Yifei Sanjie Formula (YFSJF) is an effective formula on pulmonary fibrosis (PF), which has been used in clinic for more than 30 years. In order to investigate the molecular mechanism of YFSJF in treating PF, network pharmacology was used to predict the cooperative ingredients and associated pathways. Methods. Firstly, we collected potential active ingredients of YFSJF by TCMSP databases. Secondly, we obtained PF-associated targets through OMIM and Genecards database. Finally, metascape was applied for the analysis of GO terms and KEGG pathways. Results. We screened out 76 potential active ingredients and 98 associated proteins. A total of 5715 items were obtained by GO enrichment analysis (P
Databáze: OpenAIRE
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