| Autor: |
Li, Zhi-Ran, Yang, Qin, Zhou, Tao, Huang, Yan-Hua, Zhang, Hua-Zhu, Meng, Rui, He, Gong-Hao |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
BioMed Research International. |
| ISSN: |
2314-6133 |
| DOI: |
10.1155/2020/8847401 |
| Popis: |
Background. Numerous recent studies suggested that overexpression of the long noncoding RNA small nucleolar RNA host gene 12 (SNHG12) exhibited prooncogenic activity in multiple cancers. However, results regarding the prognostic value of SNHG12 in cancers still remained controversial. Therefore, we conducted a meta-analysis complemented with bioinformatics analysis to elucidate the clinical significance of SNHG12 in cancer patients. Methods. PubMed, Embase, Cochrane Library, Chinese National Knowledge Infrastructure, Wanfang, and Weipu databases were searched for eligible studies until July 2020. Additionally, bioinformatics analysis was applied to verify the results of meta-analysis. Results. Twenty-three related studies consisting of 1389 cancer patients were enrolled in the current meta-analysis. Elevated SNHG12 expression was found to be significantly associated with poor overall survival (OS) (HR=1.81; 95% CI: 1.53-2.13; P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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