Ectopic Cushing’s Syndrome Secondary to Metastatic Paraganglioma

Autor: Daya, R., Wingfield, C., Sotshononda, P., Seedat, F., Bulbulia, S., Simmons, M. D., Louw, M., Bayat, Z.
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Case Reports in Endocrinology.
ISSN: 2090-6501
DOI: 10.1155/2021/5593920
Popis: Paraneoplastic or ectopic Cushing’s syndrome (CS) is a rare cause of endogenous hypercortisolism. It is due to ectopic adrenocorticotropic hormone (ACTH) secretion and has been reported in association with a variety of neuroendocrine tumors such as small-cell lung carcinoma, carcinoid tumors, and medullary carcinoma of the thyroid. Paragangliomas (PGLs) are rare neuroendocrine tumors that can secrete catecholamines. Case reports and reports of ectopic ACTH secretion from metastatic PGLs causing CS are exceedingly rare. We present a case of a 38-year-old female, who presented with typical signs, symptoms, and complications of CS, secondary to a PGL with widespread metastases, which eventually led to her demise.
Databáze: OpenAIRE