| Autor: |
Gallastegui, Nicolas, Cassidy, Daniel P., Heros, Deborah O., Vega, Francisco, Schatz, Jonathan H. |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Case Reports in Hematology. |
| ISSN: |
2090-6560 |
| DOI: |
10.1155/2019/1825491 |
| Popis: |
Involvement of the central nervous system by chronic lymphocytic leukemia/small lymphocytic lymphoma is exceedingly rare, and currently no risk factors have been described. We report the case of a patient with concomitant chronic lymphocytic leukemia/small lymphocytic lymphoma and an embolic cerebrovascular accident related to a cardiac myxoma, who developed parenchymal central nervous system involvement of lymphoma on the ischemic bed. The patient was successfully treated with a high-dose fludarabine-based chemotherapy regimen, achieving a sustained remission. We propose that embolic breakage of the blood-brain barrier may be a major risk factor in producing central nervous system involvement. We also propose that a high-dose fludarabine-based chemotherapy regimen may be adequate to achieve a better CNS penetration and improved outcomes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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