| Autor: |
Inoue, Ikuo, Takenaka, Yasuhiro, Kin, Yoshitora, Yamazaki, Satoshi, Ikegami, Yuichi, Saito, Daigo, Shimada, Akira |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Case Reports in Hematology. |
| ISSN: |
2090-6560 |
| DOI: |
10.1155/2020/3281626 |
| Popis: |
A 72-year-old man with a 10-year history of coronary heart disease started evolocumab treatment once a month after developing excess myalgia due to therapy with a 3-hydroxy-methylglutaryl CoA reductase inhibitor. No side effects such as myalgia symptoms had been reported during the first 14 months of evolocumab treatment; however, he suddenly presented with acute severe thrombocytopenia following the 14th treatment. His platelet count continued to decrease to a nadir of 1,000/μL. His platelet-associated immunoglobulin G level had elevated to 790 ng/107 cells. He started receiving a combination of steroid therapy, high-dose immunoglobulin therapy, and platelet transfusions, but the first-line therapy was ineffective. He was subsequently treated with a thrombopoietin receptor agonist, and his platelet count recovered to 250,000/μL. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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