| Autor: |
Ayza, Muluken Altaye, Zewdie, Kaleab Alemayehu, Tesfaye, Bekalu Amare, Wondafrash, Dawit Zewdu, Berhe, Abera Hadgu |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Oxidative Medicine and Cellular Longevity. |
| ISSN: |
1942-0900 |
| DOI: |
10.1155/2020/4965171 |
| Popis: |
The chemotherapeutic and immunosuppressive agent cyclophosphamide has previously been shown to induce complications within the setting of bone marrow transplantation. More recently, cardiotoxicity has been shown to be a dose-limiting factor during cyclophosphamide therapy, and cardiooncology is getting wider attention. Though mechanism of cyclophosphamide-induced cardiotoxicity is not completely understood, it is thought to encompass oxidative and nitrative stress. As such, this review focuses on antioxidants and their role in preventing or ameliorating cyclophosphamide-induced cardiotoxicity. It will give special emphasis to the cardioprotective effects of natural, plant-derived antioxidants that have garnered significant interest in recent times. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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