| Autor: |
Gimeno Brias, Silvia, Stack, Gabrielle, Stacey, Maria A., Redwood, Alec J., Humphreys, Ian R. |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Frontiers in Immunology. 7 |
| ISSN: |
1664-3224 |
| DOI: |
10.3389/fimmu.2016.00211 |
| Popis: |
Interleukin-22 (IL-22) is a member of the IL-10 family of cytokines. Hematopoietic cells express IL-22, and this cytokine signals through the heterodimeric IL-22 receptor expressed by non-hematopoietic cells. A growing body of evidence points toward a role for IL-22 in a diverse array of biological functions ranging from cellular proliferation, tissue protection and regeneration, and inflammation. In recent years, the role that IL-22 plays in antiviral immune responses has been examined in a number of infection models. Herein, we assess our current understanding of how IL-22 determines the outcome of viral infections and define common mechanisms that are evident from, sometimes paradoxical, findings derived from these studies. Finally, we discuss the potential therapeutic utility of IL-22 manipulation in the treatment and prevention of viral infections and associated pathologies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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