| Popis: |
The present invention is concerned with novel imidazo[1,2-a](pyrrolo, thieno or furano)[3,2-d]azepines of formula (I), the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of the dotted lines independently represents an optional bond; R?1 represents hydrogen, C1-4?alkyl, halo, ethenyl substituted with hydroxycarbonyl or C1-4?alkyloxycarbonyl, hydroxyC1-4?alkyl, formyl, hydroxycarbonyl or hydroxycarbonylC1-4?alkyl; R?2 represents hydrogen, C1-4?alkyl, ethenyl substituted with hydroxycarbonyl or C1-4?alkyloxycarbonyl, C1-4?alkyl substituted with hydroxycarbonyl or C1-4?alkyloxycarbonyl, hydroxyC1-4?alkyl, formyl or hydroxycarbonyl; R?3 represents hydrogen, C1-4?alkyl, hydroxyC1-4?alkyl, phenyl or halo; L represents hydrogen; C1-6?alkyl; C1-6?alkyl substituted with one substituent selected from the group consisting of hydroxy, halo, C1-4?alkyloxy, hydroxycarbonyl, C1-4?alkyloxycarbonyl, C1-4?alkyloxycarbonylC1-4?alkyloxy, hydroxycarbonylC1-4?alkyloxy, C1-4?alkyloxycarbonylamino, C1-4?alkylaminocarbonyl, C1-4?alkylaminocarbonylamino, C1-4?alkylaminothiocarbonylamino, aryl, aryloxy and arylcarbonyl; C1-6?alkyl substituted with both hydroxy and aryloxy; C3-6?alkenyl; C3-6?alkenyl substituted with aryl; L represents a radical of formula -Alk-Y-Het?1 (a-1), -Alk-NH-CO-Het?2 (a-2) or -Alk-Het?3 (a-3); which are useful antiallergic compounds. Compositions comprising said compounds, methods of using, and processes for preparing the same. |
