Tableting properties of an improved spray-dried lactose

Jazyk:	angličtina
Rok vydání:	2006
Předmět:	direct compaction direct compression tablets spray-dried lactose AMORPHOUS LACTOSE EXCIPIENTS filler-binders CRYSTALLINE PARTICLE-SIZE COMPACTION
Zdroj:	Journal of drug delivery science and technology. 16(6):455-459
ISSN:	1773-2247
Popis:	Spray-dried lactose is one of the most widely used filler-binders for direct compaction. The compactibility is a function of both primary particle size and the presence of amorphous lactose. Commercially available spray-dried lactose contains 15-20% amorphous lactose and 80-85% alpha-lactose monohydrate. A better understanding of the relationship between particle structure, physical properties and mechanisms of consolidation and compaction enabled an improved spray-dried lactose to be developed. The agglomerates of the improved product contain smaller primary a-lactose monohydrate particles than those of regular products. The present study shows that the improved spray-dried lactose has better compaction properties than regular spray-dried lactose.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=dris___01423::a36bc4e9ef534708e248ff2e0192d363 https://research.rug.nl/en/publications/a9afd60d-3a06-47c6-b0f8-ec88ce4e44a2 Zobrazit plný text záznamu Full Text from ScienceDirect