Antineutrophil cytoplasmic autoantibody-associated small-vessel vasculitis
| Jazyk: | angličtina |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
ANCA-ASSOCIATED VASCULITIS
microscopic polyangiitis Churg-Strauss syndrome SYSTEMIC VASCULITIS DISEASE-ACTIVITY Wegener's granulomatosis ENDOTHELIAL-CELLS RANDOMIZED-TRIAL proteinase 3 myeloperoxidase GRANULOMATOSIS ETANERCEPT TRIAL CHURG-STRAUSS-SYNDROME WEGENERS-GRANULOMATOSIS antineutrophil cytoplasmic autoantibodies CHINESE PATIENTS CRESCENTIC GLOMERULONEPHRITIS |
| Zdroj: | CURRENT OPINION IN RHEUMATOLOGY. 19(1):17-24 |
| ISSN: | 1040-8711 |
| Popis: | Purpose of reviews This review focuses on recent advance in the diagnosis pathogenesis and treatment of antineutrophil cytoplasmic autoantibody-associated small-vessel vasculitis.Recent findings Antineutrophil cytoplasmic autoantibodies are closely associated with Wegener's granulomatosis and microscopic polyangiitis. Within the Churg - Strauss syndrome, antineutrophil cytoplasmic autoantibodies, mostly directed towards myeloperoxidase, characterize patients with glomerulonephritis and small-vessel vaculitis. There is increasing evidence that myeloperoxidase - antineutrophil cytoplasmic autoantibodies are directly involved in the pathogenesis of necrotizing vasculitis. This is less clear for proteinase 3-antineutrophil cytoplasmic autoantibodies, markers for Wegener's granulomatosis. With respect to proteinase 3-antineurtophil cytoplasmic autoantibodies, complementary proteinase 3 a peptide translated from the antisense DNA strand of proteinase 3 and homologous to several microbial peptides, may be involved in induction of proteinase 3 antineutrophil cytoplasmic autoantibodies. Currently, various controlled trials have been initiated. methotrexate has been shown to be effective for induction for remission in locoregional Wegener's granulomatosis. Other trials are underway.Summary Apart from its diagnostic potential, antineurtophil cytoplasmic autoantibodies, particularly myeloperoxidase - antineutrophil cytoplasmic autoantibodies, are directly involved in the pathogenesis of the associated vasculitides. new treatment modalities, supposedly more efficacious and less toxic than daily oral cyclophosphamide, are being tested in randomised controlled trials. |
| Databáze: | OpenAIRE |
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